![]() Art and science connection Explore the connection between art and science and how we bring together artists and Broad scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.Collaborations and consortia We join with institutions and scientists the world over to address foundational challenges in science and health.Resources, services, and tools Key scientific datasets and computational tools developed by our scientists and their collaborators.Publications A catalog of scientific papers published by our members and staff scientists.Partnering and licensing We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.This study also demonstrates that science has no boundaries: the group at iMM includes scientists from different nationalities, with different skills, from clinicians to bioinformaticians. It is the knowledge of the organism's regulation that allows to correct these pathological situations restoring the healthy balance of a well regulated system." Luís Graça says, "When the biological systems of our organism are not properly regulated, disease arises. In this way, a wide range of opportunities open up to attempt the manipulation of some of these molecules for enhanced production of antibodies in vaccines, or to decrease the production of antibodies in diseases caused by them (such as autoimmunity or allergy). The information thus obtained allowed the researchers to study, in great detail, the genes and molecules involved in regulating the production of antibodies. Using omics technology offered an incredible solution to this problem and we ended up using it." Saumya Kumar, the first author of the work, says: "When the study started four years ago, we did not have the experimental tools needed and the advances in technology have been extraordinary. Something that would have been impossible a few years ago. ![]() Now, this sequenced genome is available for scientists to study the activity of genes in hundreds of independent cells. The difficulty of the process can be appreciated if we remember that about 20 years ago the sequencing of the human genome required a large group of laboratories in several countries benefiting from a series of further developments for over 10 years. This is what we studied for hundreds of cells simultaneously," explains Luís Graça. Thus, after vaccination, when a lymphocyte starts the process of controlling the production of antibodies, it will turn on some genes and turn off others. However, a cell like a lymphocyte uses a different combination of genes compared to a neuron. "To understand the power of this technology, we must note that all of our cells have the same genes. To study this process, it was necessary to use emerging technologies for the sequencing and identification of genes in each individual cell. However, it has been very difficult to study the human cells involved in the production of antibodies after vaccination, as this process takes place in the lymph nodes and not in the blood. In the last few months, the importance of vaccine-induced antibody protection against infections like COVID-19 has become clear. ![]()
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